Cara L. Green

Dietary sugar type determines the response to protein restriction in females, but not males

The paper shows that in female mice, carbohydrate quality affects metabolic and neurological responses to low protein diets, but not in males.

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

A low protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

This study shows that a low protein diet enhances metabolic health and weight loss in mice after sleeve gastrectomy, challenging current high-protein dietary recommendations.

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer&aposs disease

This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.

SIRT3 deficiency decreases oxidative-metabolism capacity but increases lifespan under caloric restriction

This study shows that SIRT3 deficiency under caloric restriction increases lifespan but decreases aerobic capacity and mitochondrial function.