The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.
Laura F. Cavallone, Michael C. Montana, Karen Frey, Dorina Kallogjeri, James M. Wages, Thomas L. Rodebaugh, Tina L Doshi, Evan D. Kharasch, Robert W. Gereau
This study evaluates the pharmacokinetics and analgesic effects of fenobam, an mGlu5 antagonist, in healthy humans, finding variable plasma exposure and minimal analgesic effects at tested doses.
Pain · Sep 14, 2019Peer-reviewedNeuroscience