Robert W. Gereau

This study examines the relationship between sex hormone levels and endometriosis-related pain in women, finding weak associations between specific receptor transcript levels and pain intensity.

PixelPaws is an open-source platform for automated mouse behavior scoring that validates its performance against human observers in pain and opioid withdrawal assays.

The paper identifies hyperexcitable Ret/GFRα1+ nociceptors innervating endometriosis lesions that correlate with GDNF levels and clinical pain.

This study examines how combining Δ9-THC and oxycodone affects pain relief, dependence, circadian activity, and reward in mice, finding enhanced antinociception without increased dependence but with increased reward.

This study identifies Pdyn-lineage neurons as sensory enteric neurons in the mouse colon that regulate motility and visceral interoception through optogenetic activation.

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

The paper identifies CeA neuronal ensembles that modulate visceral pain and its affective behaviors through optogenetic manipulation and single-nucleus RNA sequencing.

This study examines how dopamine agonists affect pain-responsive neurons in the central nucleus of the amygdala, finding inhibitory effects on neuronal activity and synaptic transmission.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.

This study investigates the use of small molecule degraders to target voltage-gated sodium channels NaV1.8 and NaV1.7, showing their degradation via PROTACs and molecular glues involving CRBN and VHL.

The paper introduces an implantable device that autonomously detects and treats opioid overdose, improving survival rates by delivering naloxone and alerting first responders.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

This study characterizes bradykinin receptor expression and function in human dorsal root ganglia neurons, finding conserved acute hyperexcitability and age/pain history-related B1 receptor expression.

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

This study shows that oral oxycodone self-administration in mice leads to features of opioid addiction, including escalation, dependence, and relapse behavior.

The paper characterizes the transcriptional profile of Satellite Glial Cells (SGC) in mouse, rat, and human at the single-cell level, finding conserved key features across species.

This study evaluates CB-13, a peripherally selective CB1 agonist, showing it reduces pain in mice but develops tolerance and CNS effects with repeated dosing.

This study identifies itch-activated neurons in the central amygdala (CeA) and their role in itch sensation, avoidance, and comorbidities like anxiety, using RNA-sequencing and viral tracing.

This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.

The paper identifies BNST-PBN neural circuits that modulate feeding by integrating threat assessment and feeding drive.

This paper introduces an oral oxycodone self-administration paradigm in mice to model prescription opioid use and its transition to abuse.

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.

This study identifies PAG neuronal populations that modulate acute and chronic itch by differentially regulating sensory and affective components through GABAergic and glutamatergic activity.

This study evaluates the pharmacokinetics and analgesic effects of fenobam, an mGlu5 antagonist, in healthy humans, finding variable plasma exposure and minimal analgesic effects at tested doses.