Joint analysis of matched tumor samples with varying tumor contents improves somatic variant calling in the absence of a germline sample
Rebecca F. Halperin, Winnie S. Liang, Sidharth Kulkarni, Erica E. Tassone, Jonathan R. Adkins, Daniel Enriquez, Nhan L. Tran, Nicole C. Hank, James Newell, Chinnappa D. Kodira, Ronald Lee Korn, Michael E. Berens, Seungchan Kim, Sara Ann Byron
LumosVar 2.0 improves somatic variant calling by jointly analyzing tumor and adjacent normal samples without a germline reference.
bioRxiv · Jul 9, 2018 · PreprintBioinformatics