Hepatic aldose reductase drives a Warburg effect-like metabolic reprogramming to promote insulin resistance, fatty liver and obesity
Dan Song, Dianqiang Yang, Longping Wen, Feng Zheng, James Y. Yang
This study shows that hepatic aldose reductase activation causes metabolic reprogramming similar to the Warburg effect, leading to insulin resistance, fatty liver, and obesity.
bioRxiv · Sep 23, 2024 · PreprintBiochemistry