Author

Feng Zheng

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Anja HemschemeieriD· 1 shared Claudio GrecoiD· 1 shared Dan SongiD· 1 shared Dianqiang Yang· 1 shared Eckhard HofmanniD· 1 shared Eugene Koonin· 1 shared Federica ArrigoniiD· 1 shared Guilhem FaureiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

Anja HemschemeierORCID

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3 papers

Recent·Most cited

A histidine-mediated, pendulum-like proton transport mechanism is required for the high catalytic activity of -hydrogenases

Jifu Duan, Yang Zhaoya, Oliver Lampret, Federica Arrigoni, Lukas Van Impel, Feng Zheng, Julian T. Kleinhaus, Ulf‐Peter Apfel, Claudio Greco, Luca DE GIOIA, Eckhard Hofmann, Anja Hemschemeier, Thomas Happe

This study identifies a histidine-mediated pendulum mechanism in [FeFe]-hydrogenases that enhances catalytic activity by facilitating proton transfer.

bioRxiv · Sep 23, 2026 · PreprintBiochemistry

Hepatic aldose reductase drives a Warburg effect-like metabolic reprogramming to promote insulin resistance, fatty liver and obesity

Dan Song, Dianqiang Yang, Longping Wen, Feng Zheng, James Y. Yang

This study shows that hepatic aldose reductase activation causes metabolic reprogramming similar to the Warburg effect, leading to insulin resistance, fatty liver, and obesity.

bioRxiv · Sep 23, 2024 · PreprintBiochemistry

Cargo genes of Tn7-like transposons comprise an enormous diversity of defense systems, mobile genetic elements and antibiotic resistance genes

Sean Benler, Guilhem Faure, Han-Altae Tran, Sergey Shmakov, Feng Zheng, Eugene Koonin

The paper identifies cargo genes of Tn7-like transposons, revealing their role in transferring diverse genes including MGEs, defense systems, and antibiotic resistance genes.

mBio · Dec 7, 2021Peer-reviewedGenomics