Study design and rationale of Boxed-Breathing-Heart: a translational ex vivo study evaluating virus-mediated gene delivery for gene therapy in normothermic machine-perfused human hearts
Isabel Branzei, Ali Amr, Kleopatra Rapti, Laura Schraft, Dominik Lindenhofer, Albrecht Leo, Gabriele Romano, Farbod Sedaghat‐Hamedani, Christoph Reich, Jan Koelemen, Jan Haas, Ana Muñoz Verdú, Jan Beckendorf, Philipp Schlegel, W Te Gussinklo, , Benjamin Meder
The paper describes an ex vivo study using normothermic machine-perfused human hearts to evaluate AAV-mediated gene delivery for cardiac gene therapy.
medRxiv · Jul 14, 2026 · PreprintGenetic & Genomic Medicine