Dirk Grimm

The paper describes an ex vivo study using normothermic machine-perfused human hearts to evaluate AAV-mediated gene delivery for cardiac gene therapy.

This paper identifies CDC14A and KMT5A as regulators of concentric vs. eccentric cardiac remodeling through epigenomic control of gene transcription, with CDC14A as a potential therapeutic target for heart failure.

The paper uses single molecule long-read sequencing to analyze transcriptomes in heart failure patients and controls, identifying novel isoforms and convergent isoform changes across different cardiomyopathy types.

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

This study shows that targeting CD44v6/MET signaling disrupts colorectal cancer cell plasticity by repressing Lgr5+ cell reappearance and affecting YAP/TAZ signaling.

This study develops a method to efficiently induce somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9, replicating knockout phenotypes without generating knockout mice.

This study uses base editors and AAVMYO to correct Rbm20 mutations in cardiomyocytes, improving splicing and cardiac function in mouse models of dilated cardiomyopathy.

This paper develops a method to label and image AIS proteins in living neurons using unnatural amino acids and bioorthogonal click chemistry, demonstrating its application to study NaV1.6 variants.

The paper identifies sequences and proteins influencing trans splicing in Trypanosoma brucei and shows evolutionary conservation of SR-domain and PTB functions.

The paper identifies AAV variants that efficiently target adult neural stem cells in the subventricular zone, enabling genetic modification for potential regenerative therapies.

This paper introduces an optogenetic tool to control NmeCas9 activity using a light-switchable anti-CRISPR protein, enabling precise genome editing in mammalian cells.

The paper designs improved anti-CRISPR proteins with enhanced inhibition potency and expanded specificity through structure-based engineering.

This paper develops a cell-specific CRISPR/Cas9 activation system using miRNA-regulated anti-CRISPR proteins, demonstrating targeted gene activation in liver and muscle cells.

This study identifies post-transcriptional regulation by Cpeb1 as a mechanism enhancing CNS axonal regeneration in mice and Drosophila.