Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells
Simon Maria Kienle, Matthias Sigg, Tobias Schneider, Katrin Stuber, Jan Lehmann, Jasmin Jansen, Florian Stengel, Andreas Marx, Michael Kovermann, Martin Scheffner
This study introduces ketolysine (KeK), a non-hydrolyzable acetyllysine analog, which remains stable in cells and affects p53-mediated transcription, unlike acetyllysine (AcK) which is deacetylated.
Nature Communications · Feb 21, 2026Peer-reviewedBiochemistry