Andreas Marx

Human RNA ligase 1 as a novel regulator of ribosome function and translation under oxidative stress

This study identifies Rlig1 as a regulator of ribosome function and translation under oxidative stress by showing its interaction with ribosomal proteins and its role in maintaining translational activity.

Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells

This study introduces ketolysine (KeK), a non-hydrolyzable acetyllysine analog, which remains stable in cells and affects p53-mediated transcription, unlike acetyllysine (AcK) which is deacetylated.

An RNA ligase shapes transcriptional profiles, neural function, and behaviour in the developing larval zebrafish

This study shows that Rlig1 is essential for maintaining neural function and behavior in zebrafish larvae by regulating RNA processing and metabolic pathways.

The IFN I response in tumor cells is shaped by PARP7-p300/CBP interactions through distinct loss- and gain-of-function mechanisms

This paper identifies p300 and CBP as PARP7 substrates that regulate IFNβ through loss- and gain-of-function mechanisms in colorectal cancer cells.

Combining molecular dynamics simulations and scoring method to computationally model ubiquitylated linker histones in chromatosomes

This study uses molecular dynamics simulations and a geometric scoring method to model mono-ubiquitylated linker histones in chromatosomes and identify their conformational states.