Katrin Stuber

The paper uses pulsed-SILAC in single mouse embryos to study protein synthesis dynamics and phosphosite regulation during early embryogenesis, revealing active maternal proteome synthesis and post-translational regulation.

This study introduces ketolysine (KeK), a non-hydrolyzable acetyllysine analog, which remains stable in cells and affects p53-mediated transcription, unlike acetyllysine (AcK) which is deacetylated.