Treatment with saturating dose of conventional anti-CD28 monoclonal antibody well tolerated in pig acute myocardial infarction model
Anja Stadtmüller, Rebekka Grampp, Giulia Marianantoni, Florian Schnitter, Finja Becker, Könül Nuriyeva, Daniela Langenhorst, Leona Metka, Kira Günther, Lars Wiebusch, Kerstin H. Mair, Nadine Gladow, Thomas Herrmann, Jan Rohr, Ulrich Hofmann, , Beyersdorf Niklas
This study shows that a conventional anti-CD28 mAb is well tolerated in pigs after MI and promotes Treg accumulation in the infarcted heart.
Frontiers in Immunology · Aug 11, 2026Peer-reviewedImmunology