Ulrich Hofmann

This study shows that a conventional anti-CD28 mAb is well tolerated in pigs after MI and promotes Treg accumulation in the infarcted heart.

This study shows CD4+ T cells drive cardiomyopathy in Duchenne muscular dystrophy by promoting fibrosis and dysfunction, using Mdx mice and single-cell RNA sequencing.

This study shows low-dose CD28-SA infusion reduces inflammation and promotes wound healing in pigs after myocardial infarction by increasing Treg cells and reducing TNF-producing cells.

This study shows that IFN-gamma signaling in cardiomyocytes causes metabolic changes in the heart, including increased glucose uptake and reduced oxidative phosphorylation, which resemble changes in aging and heart failure.