Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model
Bettina Welz, Saul Pierotti, Tomas W. Fitzgerald, Thomas Thumberger, Risa Suzuki, Philip Watson, Jana Fuss, Tiago Cordeiro da Trindade, Fanny Defranoux, Marcio Soares Ferreira, Kiyoshi Naruse, Felix Loosli, Jakob Gierten, Joachim Wittbrodt, Ewan Birney
The paper uses medaka fish to study genetic and environmental interactions in heart rate, identifying QTLs and validating genes, while showing limitations of GWAS in capturing complex genetic effects.
bioRxiv · Apr 24, 2025 · PreprintGenetics