Jakob Gierten

The paper maps and validates key genetic loci influencing heart rate and function in fish, identifying potential targets for cardiac disease treatment.

The paper uses medaka fish to study genetic and environmental interactions in heart rate, identifying QTLs and validating genes, while showing limitations of GWAS in capturing complex genetic effects.

The paper develops a base editing framework in medaka and zebrafish to functionally validate SNVs, demonstrating its application in recreating cardiac phenotypes and validating candidate genes for congenital heart disease.

The paper introduces the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel, a vertebrate genetic resource for genotype-to-phenotype studies, enabling controlled experiments on complex traits.

The paper analyzes genomic and epigenomic variation in the MIKK panel using long-read sequencing and pan-genome graphs, revealing novel structural variants and methylation patterns.

The paper identifies and validates 16 GWAS candidates with potential predictive power for human cardiovascular diseases using CRISPR/Cas9 in medaka.

The paper identifies genetic associations with myocardial trabecular complexity using UK Biobank data and shows a causal link to ventricular function and electrical activity.

The paper develops an automated high-throughput method for measuring heart rate in medaka and zebrafish embryos without anesthesia or fluorescent reporters.