Author

Janet S. Ziegle

Pacific Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alisha M. BirkiD· 1 shared Anna VilborgiD· 1 shared Aradhana SachdeviD· 1 shared Austin P. So· 1 shared Bruce R. ConkliniD· 1 shared Claire Dudley ClellandiD· 1 shared Daniel MendozaiD· 1 shared Federico M. GoodsaidiD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alisha M. BirkORCID

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2 papers

Recent·Most cited

Two therapeutic CRISPR/Cas9 gene editing approaches revert FTD/ALS cellular pathology caused by a C9orf72 repeat expansion mutation in patient derived cells

Maria Sckaff, Kamaljot Gill, Aradhana Sachdev, Alisha M. Birk, Olubankole Aladesuyi Arogundade, HL Watry, Kathleen C. Keough, Y-C Tsai, Janet S. Ziegle, Bruce R. Conklin, Claire Dudley Clelland

This study evaluates three CRISPR/Cas9 approaches to correct C9orf72 repeat expansion in patient-derived neurons, finding that repeat and mutant allele excision fully eliminate dipeptide repeats.

bioRxiv · May 21, 2022 · PreprintNeuroscience

A Robust Targeted Sequencing Approach For Low Input And Variable Quality DNA From Clinical Samples

Austin P. So, Anna Vilborg, Yosr Bouhlal, Ryan T. Koehler, Susan M. Grimes, Yannick Pouliot, Daniel Mendoza, Janet S. Ziegle, Jason B. Stein, Federico M. Goodsaid, Michael Y. Lucero, Francisco M. De La Vega, Hanlee P. Ji

This paper introduces a targeted sequencing method for low-quality DNA that reduces PCR bias and improves variant detection in clinical samples.

npj Genomic Medicine · Jan 5, 2018Peer-reviewedGenomics