EGR1 Mediates Riluzole-Induced Apoptosis in Osteosarcoma via the Yap/p73-Bax Signaling Axis
Syeda Maryam Azeem, Shraddha ChandThakuri, Pooja Prakash Rao, Tamia Abbasi, Jannae McFarlane, Raisa Munira, Sahanama Porshe, Vinagolu K. Rajasekhar, John H. Healey, Shahana S. Mahajan
This study shows Riluzole induces apoptosis in osteosarcoma by upregulating EGR1, which interacts with Yap/p73 to enhance Bax expression and promote cell death.
bioRxiv · Oct 15, 2025 · PreprintCancer Biology