EphrinA5 regulates cell motility by modulating the targeting of DNMT1 to the Ncam1 promoter via lncRNA/DNA triplex formation
Can Bora Yildiz, Tathagata Kundu, Julia Gehrmann, Jannis Koesling, Amin Ravaei, Mira Jakovcevski, Daniel Pensold, Olav Zimmermann, Giulia Rossetti, Ivan G. Costa, Geraldine Zimmer‐Bensch
The paper shows ephrinA5 reduces cell motility by decreasing Snhg15 expression, which lowers DNMT1 binding to the Ncam1 promoter, reducing methylation and increasing Ncam1 expression.
bioRxiv · Mar 25, 2023 · PreprintMolecular Biology