The phosphodiesterase NbdA links c-di-GMP signaling to type IV pili function in Pseudomonas aeruginosa PAO1
Anna Scherhag, Katrin Aras, Martina Ledermann, Jaqueline Rehner, Maike Karcher, Hanna Becker, Simone Stegmüller, Elke Richling, Nicole Frankenberg‐Dinkel, Susanne Zehner
This paper shows that NbdA, a phosphodiesterase in Pseudomonas aeruginosa, modulates c-di-GMP levels and affects type IV pilus function, influencing surface behavior and phage resistance.
bioRxiv · Mar 23, 2026 · PreprintMicrobiology