Clonal haematopoiesis without identified genetic drivers: insights from analyses of 407,512 individuals
Sean Wen, Rafael Campos, Marcin Karpiński, Rahul Sharma, Veselin Manojlović, Sri V. V. Deevi, Sean O’Dell, Xiaoyin Li, Fengyuan Hu, Jared O’Connell, Abhishek Nag, Karyn Mégy, Stewart MacArthur, Sebastian Wasilewski, Xueqing Zoe Zou, , Jonathan Mitchell
This study identifies 26,963 individuals with clonal haematopoiesis without known genetic drivers (CH-UD) and finds strong genetic and phenotypic links to other forms of clonal haematopoiesis, implicating TCL1A and epigenetic changes.
medRxiv · May 21, 2026 · PreprintGenetic & Genomic Medicine