The Impact of Non-coding G-quadruplex Variants on Human Traits and Disease Susceptibility
Rahul Sharma, Fengyuan Hu, Xiaoyin Li, Rafael Campos, Kousik Kundu, Santosh S. Atanur, Marcin Karpiński, Sebastian Wasilewski, Stewart MacArthur, Dimitrios Vitsios, Ryan S. Dhindsa, Ilias Georgakopoulos‐Soares, Oliver S. Burren, Slavé Petrovski, Anthony M. Mustoe, , Xueqing Zoe Zou
The paper identifies non-coding G-quadruplex variants associated with plasma proteins and clinical traits, showing stronger signals when considering G4 stability impacts and integrating with protein-truncating variants.
medRxiv · Jun 1, 2026 · PreprintGenetic & Genomic Medicine