Author

Sean Wen

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Abhishek NagiD· 3 shared Fengyuan HuiD· 3 shared Jonathan MitchelliD· 3 shared Margarete A. FabreiD· 3 shared Quanli WangiD· 3 shared Sebastian Wasilewski· 3 shared Slavé PetrovskiiD· 3 shared Sri V. V. DeeviiD· 3 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Abhishek NagORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Clonal haematopoiesis without identified genetic drivers: insights from analyses of 407,512 individuals

Sean Wen, Rafael Campos, Marcin Karpiński, Rahul Sharma, Veselin Manojlović, Sri V. V. Deevi, Sean O’Dell, Xiaoyin Li, Fengyuan Hu, Jared O’Connell, Abhishek Nag, Karyn Mégy, Stewart MacArthur, Sebastian Wasilewski, Xueqing Zoe Zou, , Jonathan Mitchell

This study identifies 26,963 individuals with clonal haematopoiesis without known genetic drivers (CH-UD) and finds strong genetic and phenotypic links to other forms of clonal haematopoiesis, implicating TCL1A and epigenetic changes.

medRxiv · May 21, 2026 · PreprintGenetic & Genomic Medicine

Robust CRISPR/dCas13 RNA blockers specifically perturb miRNA-target interactions and rescue type 1 myotonic dystrophy pathology

Muhammad Hanifi, Perihan Seda Ateş, Sean Wen, Mathieu Fischer, Amanda E Kroesen, Zulin Yu, Matthew Wood, Supat Thongjuea, Adam J. Mead, Tudor A. Fulga, Carlo Rinaldi, Tatjana Sauka‐Spengler

This paper develops CRISPR-Lock, a CRISPR/dCas13 RNA blocker that disrupts miRNA-target interactions and rescues DM1 pathology by correcting splicing biomarkers and reducing nuclear foci.

bioRxiv · Sep 16, 2024 · PreprintBioengineering

BRACE: A novel Bayesian-based imputation approach for dimension reduction analysis of alternative splicing at single-cell resolution

Sean Wen

BRACE improves imputation of alternative splicing data for single-cell dimension reduction analysis and applies it to diverse datasets.

bioRxiv · Aug 1, 2024 · PreprintBioinformatics

Comparative analysis of 136,401 Admixed Americans and 419,228 Europeans reveals ancestry-specific genetic determinants of clonal haematopoiesis

Sean Wen, Pablo Antonio Kuri-Morales, Fengyuan Hu, Abhishek Nag, Ioanna Tachmazidou, Sri V. V. Deevi, Haeyam Taiy, Katherine R. Smith, Douglas P. Loesch, Oliver S. Burren, Ryan S. Dhindsa, Sebastian Wasilewski, Jesús Alegre-Díaz, Jaime Berumen-Campos, Jonathan Emberson, , Jonathan Mitchell

This study compares clonal haematopoiesis (CH) between admixed Americans and Europeans, finding ancestry-specific genetic factors and lower CH prevalence in admixed populations.

medRxiv · Feb 7, 2024 · PreprintGenetic & Genomic Medicine

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequences

Oliver S. Burren, Ryan S. Dhindsa, Sri V. V. Deevi, Sean Wen, Abhishek Nag, Jonathan Mitchell, Fengyuan Hu, Katherine R. Smith, Neetu Razdan, Henric Olsson, Adam Platt, Dimitrios Vitsios, Qiang Wu, AstraZeneca Genomics Initiative, Veryan Codd, , Slavé Petrovski

The paper identifies 53 rare variants and 22 genes associated with telomere length using UK Biobank whole-genome sequences, highlighting their role in clonal haematopoiesis and disease.

medRxiv · Sep 18, 2023 · PreprintGenetic & Genomic Medicine