Sex specific emergence of trisomic Dyrk1a-related skeletal phenotypes in the development of a Down syndrome mouse model
Jonathan LaCombe, Kourtney Sloan, Jared R. Thomas, Matthew P. Blackwell, Isabella Crawford, Joseph Michael Wallace, Randall J. Roper
The paper analyzes bone development and gene expression in Ts65Dn mice to identify timepoints when trisomic Dyrk1a overexpression links to skeletal abnormalities, showing sex-dependent differences in deficit timing and resolution.
bioRxiv · May 24, 2024 · PreprintGenetics