Joseph Michael Wallace

This study examines how Clcn7 mutations in mice affect bone phenotypes, showing increased trabecular bone mass with variations based on age, sex, genetic background, and mutation type.

The paper compares skeletal phenotypes between two Down syndrome mouse models, Ts65Dn and Ts66Yah, using a novel PCA-based method to assess the impact of non-Hsa21 trisomic genes on bone structure and function.

The paper analyzes bone development and gene expression in Ts65Dn mice to identify timepoints when trisomic Dyrk1a overexpression links to skeletal abnormalities, showing sex-dependent differences in deficit timing and resolution.