Restoration of Sp4 in forebrain GABAergic neurons rescues hypersensitivity to ketamine in Sp4 hypomorphic mice
Kerin K Higa, Baohu Ji, Mahalah R Buell, Risbrough B Victoria, Susan B Powell, Jared W Young, Mark A Geyer, Xianjin Zhou
The paper restores Sp4 expression in specific forebrain neuron types in Sp4 hypomorphic mice and shows that GABAergic neuron restoration rescues ketamine-induced hyperlocomotion.
bioRxiv · Feb 26, 2015Neuroscience