Xianjin Zhou

Abnormal X Chromosome Inactivation in Females with Major Psychiatric Disorders

This study identifies abnormal X chromosome inactivation in female psychiatric patients, suggesting it may contribute to disease development and offer potential diagnostic and therapeutic targets.

Restoration of Sp4 in forebrain GABAergic neurons rescues hypersensitivity to ketamine in Sp4 hypomorphic mice

The paper restores Sp4 expression in specific forebrain neuron types in Sp4 hypomorphic mice and shows that GABAergic neuron restoration rescues ketamine-induced hyperlocomotion.

Boymaw, Overexpressed in Brains with Major Psychiatric Disorders, May Encode a Small Protein to Inhibit Mitochondrial Function and Protein Translation

The paper identifies Boymaw as a gene that encodes a small mitochondrial protein which inhibits oxidoreductase activity, rRNA expression, and protein translation, and is upregulated in psychiatric disorders.

Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders

This study shows that the DISC1-Boymaw fusion gene inhibits protein translation and contributes to psychiatric disorders in a Scottish family.