SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinase
Pinja Kettunen, Angelina Lesnikova, Noora Räsänen, Ravi Ojha, Leena Palmunen, Markku Laakso, Šárka Lehtonen, Johanna Kuusisto, Olli P. H. Pietiläinen, Olli P. Vapalahti, Jari Kostinaho, Taisia Rõlova, Giuseppe Balistreri
This study shows that SARS-CoV-2 can infect a small fraction of human cortical neurons via the endosomal pathway, and this infection can be blocked by apilimod.
bioRxiv · Sep 14, 2022 · PreprintNeuroscience