Olli P. Vapalahti

This study designs and validates protease-resistant antiviral peptides that inhibit SARS-CoV-2 fusion, showing improved efficacy in vitro and in vivo.

LazypipeX improves virus discovery in mNGS data by offering customizable and efficient annotation strategies that reduce execution time while maintaining accuracy.

The paper investigates TBEV circulation and vertical transmission in bank voles in Poland, finding co-circulating viral lineages and evidence of vertical transmission.

This study identifies zoonotic viruses in Kenyan rodents and shrews, including rat hepatitis E virus and novel paramyxoviruses, highlighting the need for genomic surveillance.

The paper reprocesses SARS-CoV-2 genomic data to correct systematic errors in phylogenies using a novel assembly tool, resulting in a cleaner global tree of 4.47 million samples.

The paper develops a SARS-CoV-2 vaccine in mink and evaluates its immune response and efficacy against Alpha and Omicron variants, showing reduced severity and virus presence in vaccinated animals.

This study shows JAK inhibitors like baricitinib suppress IFN-stimulated genes, aiding viral propagation by reducing antiviral defenses.

This paper determines the crystal structure of an engineered antibody diabody bound to rabies virus glycoprotein, revealing a conserved epitope and mechanism of neutralization.

The paper examines circulating mucosal-like IgA responses in Puumala orthohantavirus infection and finds they correlate with AKI severity and pro-inflammatory effects.

This study uses sewage metagenomics to distinguish seasonal, human-derived, and environmental microbial communities, offering potential for improved AMR surveillance.

The paper identifies and characterizes neutrophil subsets in PUUV-HFRS patients, finding that low-density granulocytes (LDGs) correlate with thrombocytopenia and may reflect increased bone marrow production.

The paper identifies a critical epitope on PUUV Gc targeted by neutralizing antibodies and shows that mutations in this region confer neutralization escape.

This paper introduces Lazypipe2, an improved metagenomic pipeline for virus detection, showing enhanced performance in identifying eukaryotic viruses and handling divergent sequences.

This study shows that SARS-CoV-2 can infect a small fraction of human cortical neurons via the endosomal pathway, and this infection can be blocked by apilimod.

ClusTRace is a bioinformatic pipeline for analyzing clusters in SARS-CoV-2 phylogenies to detect super-spreading events and novel mutations.

The paper analyzes SARS-CoV-2 genomic data from Iraq during 2020-2021, identifying a high prevalence of the B.1.1.7 lineage with a stop codon mutation in ORF7a.

HaVoC is a bioinformatic pipeline that assembles SARS-CoV-2 sequences and identifies lineages to detect variants of concern.

The paper introduces a novel NGS pipeline called LAZYPIPE for virus discovery across diverse hosts and samples, demonstrating its ability to identify both known and novel viruses.

This study describes a protocol to generate hindbrain-like human brain organoids with mature, functional neurons and reports their response to Zika virus and anticonvulsants.