Collateral sensitivities with predictive signatures emerge in a novel model of evolved chemoresistance in osteosarcoma
Zachary D. C. Burke, Kristi Lin‐Rahardja, Gabriel Mandel, Jarrell Imamura, Arda Durmaz, Elizabeth Nowak, Masahiro Hitomi, Jacob G. Scott
This study develops an in vitro model of osteosarcoma chemoresistance and identifies predictive gene expression signatures for collateral drug responses to guide second-line treatment.
bioRxiv · Aug 11, 2026 · PreprintCancer Biology