Author

Zachary D. C. Burke

Cleveland ClinicORCID 0000-0001-9601-0956Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Arda DurmaziD· 2 shared Jacob G. ScottiD· 2 shared Amira Stocks· 1 shared Dena CrozieriD· 1 shared Elizabeth Nowak· 1 shared Gabriel MandeliD· 1 shared J. A. MaltasiD· 1 shared Jarrell Imamura· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Arda DurmazORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 11, 2026

Collateral sensitivities with predictive signatures emerge in a novel model of evolved chemoresistance in osteosarcoma

Zachary D. C. Burke, Kristi Lin‐Rahardja, Gabriel Mandel…·Jacob G. Scott

This study develops an in vitro model of osteosarcoma chemoresistance and identifies predictive gene expression signatures for collateral drug responses to guide second-line treatment.

DOI 10.64898/2026.08.10.743977

humanbulk RNA-seq

𝕏 PostBluesky

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedSep 25, 2025

Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus

Kyle J. Card, Dena Crozier, Arda Durmaz…·Jacob G. Scott

This study evolves Staphylococcus aureus under vancomycin selection, revealing two distinct adaptive pathways that lead to divergent collateral sensitivity patterns to first-line antibiotics.

8 citationstop 5%

bacteria (other)whole-genome sequencing

𝕏 PostBluesky