Kristi Lin‐Rahardja

This study develops an in vitro model of osteosarcoma chemoresistance and identifies predictive gene expression signatures for collateral drug responses to guide second-line treatment.

The paper experimentally evolves resistance in Ewings sarcoma cell lines to identify gene expression signatures predicting collateral drug responses, validated in an independent cell line.

This paper introduces a framework called the chemogram to rank drug sensitivity using transcriptomic signatures, showing improved accuracy over random predictions for multiple chemotherapy drugs.