Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci
William S. Henriques, Jarrett Bowman, Laina N. Hall, Colin C. Gauvin, Hui Alex Wei, Huihui Kuang, Christina M. Zimanyi, Edward T. Eng, Andrew Santiago‐Frangos, Blake Wiedenheft
The paper determines structures of the Cas1-2/3 complex to elucidate how it captures, delivers, and integrates foreign DNA into CRISPR loci.
Structure · Oct 10, 2025Peer-reviewedMolecular Biology