FAM57B is a modulator of ceramide synthesis that regulates sphingolipid homeostasis and synaptic composition in the developing brain
Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour, Jasmine M. McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H. Futerman, Hazel L. Sive
This study identifies FAM57B as a regulator of ceramide synthesis and sphingolipid homeostasis in 16pdel Syndrome, linking it to synaptic dysfunction and neurological symptoms.
iScience · Dec 2, 2021Peer-reviewedNeuroscience