Rudolf Jaenisch

The paper develops a protocol to model insulin sensitivity and resistance in multiple hPSC-derived cell types, showing insulin resistance across various cell types under diabetic conditions.

The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.

This study develops a feeder-free method to generate functional human dendritic cells from pluripotent stem cells, outperforming monocyte-derived dendritic cells in antigen presentation and T cell activation.

This study genetically engineers mice to produce a protective antibody against Lyme disease, demonstrating heritable immunity that interrupts pathogen transmission.

This study develops a human BBB model using NCC-PCs to show they protect against viral neuroinvasion by maintaining BMEC barrier integrity.

This study evaluates inducible transgenic systems in human pluripotent stem cells and differentiated cells, identifying a small molecule-mediated splicing switch that enables tunable transgene expression without protein tags.

This study uses CRISPR/Cas9 to knockout Gat3 in mouse visual cortex astrocytes, revealing its role in shaping neuronal activity and sensory information encoding.

The paper shows healthy adipocytes protect neighboring cells from viral infection through STING-dependent interferon-alpha secretion, and metabolic dysfunction reduces this antiviral activity.

This study compares pathogenesis of ancestral and contemporary Zika viruses in human cerebral organoids, finding differential signaling responses and identifying ROS imbalance as a key driver, which is mitigated by Trolox.

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

This study shows that FLT3 inhibition promotes neuronal maturation and reduces seizures in a mouse model by upregulating KCC2 and reducing neuroinflammation.

This study shows that RTT astrocytes release dysfunctional mitochondria, disrupting neuronal activity and cerebral organoid development through impaired energy metabolism and mitochondrial dysfunction.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

This study identifies GPX4 as a conserved suppressor of cold-induced cell death through multi-species CRISPR screens in hibernators and non-hibernators.

This study shows that human-specific SRGAP2B/C paralogs drive neotenic microglia maturation and influence synaptic development in human brains.

This paper develops a Cpf1-based system for efficient multiplex genome editing in human pluripotent stem cells, achieving targeted knockin and knockout with minimal off-target effects.

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

The paper detects SARS-CoV-2 retrotransposition into host genomes via LINE1 in infected cells but not in transfected cells, using WGS and TagMap methods.

This study shows that human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 WA1/2020 and its variants delta and omicron, but cannot produce new viruses.

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.

This study identifies FAM57B as a regulator of ceramide synthesis and sphingolipid homeostasis in 16pdel Syndrome, linking it to synaptic dysfunction and neurological symptoms.

SARS-CoV-2 RNA can be reverse-transcribed by LINE-1 or HIV-1 reverse transcriptase, integrated into the human genome, and transcribed as chimeric viral-cellular RNAs.

The paper shows that restoring over 5% FMRP expression or 20% FMRP-positive neurons in FXS neurons normalizes hyperactivity.

The paper investigates the role of JIP2 haploinsufficiency in neurodevelopmental abnormalities using human pluripotent stem cells and finds that it impairs neuronal maturation through JNK misregulation and compromised semaphorin signaling.

Optimal transport converts a 65,781-cell reprogramming time course into probabilistic fates and trajectories, exposing alternative cell fates and a gene, Obox6, that improves reprogramming efficiency.

This study shows that ZIKV infects neural progenitors, astrocytes, and microglia-like cells, with microglia acting as viral reservoirs and facilitating infection of the fetal brain.