Author

Danielle L. Tomasello

Whitehead Institute for Biomedical ResearchORCID 0000-0001-8891-4306Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Rudolf JaenischiD· 4 shared Abigail K. R. Lytton‐JeaniD· 1 shared Alexandria R. Barlowe· 1 shared Alexsia L. Richards· 1 shared Anthony FlamieriD· 1 shared Anthony H. FutermaniD· 1 shared David V. MankusiD· 1 shared Ernest FraenkeliD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

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10 top collaborators · 15 mutual co-author links

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4 shared papersNeuroscience

Rudolf JaenischORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 11, 2026

IGF1 peptide targets Rett Syndrome astrocytes to degrade IGF binding protein, rescue synaptogenesis and restore mitochondrial function

Prachi Ojha, Velina Kozareva, Alexandria R. Barlowe…·Mriganka Sur

The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.

DOI 10.64898/2026.01.22.701190

mouseproteomics

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NeuroscienceScientific ReportsPeer-reviewedSep 4, 2024

Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondria

Danielle L. Tomasello, M. Inmaculada Barrasa, David V. Mankus…·Rudolf Jaenisch

This study shows that RTT astrocytes release dysfunctional mitochondria, disrupting neuronal activity and cerebral organoid development through impaired energy metabolism and mitochondrial dysfunction.

27 citationstop 2%

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJan 10, 2023

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 strain WA1/2020 as well as variants delta and omicron.

Anthony Flamier, Punam Bisht, Alexsia L. Richards…·Rudolf Jaenisch

This study shows that human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 WA1/2020 and its variants delta and omicron, but cannot produce new viruses.

3 citations

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NeuroscienceiSciencePeer-reviewedDec 2, 2021

FAM57B is a modulator of ceramide synthesis that regulates sphingolipid homeostasis and synaptic composition in the developing brain

Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour…·Hazel L. Sive

This study identifies FAM57B as a regulator of ceramide synthesis and sphingolipid homeostasis in 16pdel Syndrome, linking it to synaptic dysfunction and neurological symptoms.

27 citations

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