A novel and efficient machine learning Mendelian randomization estimator applied to predict the safety and efficacy of sclerostin inhibition
Marc‐André Legault, Jason Hartford, Benoît J. Arsenault, Archer Yi Yang, Joëlle Pineau
This paper introduces a machine learning Mendelian randomization estimator, Quantile IV, to assess the causal effects of sclerostin inhibition on bone and cardiovascular outcomes using UK Biobank data.
The American Journal of Human Genetics · May 15, 2025Peer-reviewedGenetic & Genomic Medicine