Marc‐André Legault

BiomiX 3.0 is a multi-omics integration platform that introduces PRAMIGO, a supervised heterogeneous graph transformer, and benchmarks five methods on CLL and PTB datasets, showing that no single method captures all biologically relevant signals.

This study shows that CETP isoforms influence human traits, particularly in pituitary and thyroid glands, and reveals tissue-specific CVD associations and epistatic interactions involving ADCY9.

This study uses polygenic scores to show asthma genetics are linked to ACS recurrence risk, but not occurrence, and highlights the role of HbF in modulating this risk.

This paper introduces a machine learning Mendelian randomization estimator, Quantile IV, to assess the causal effects of sclerostin inhibition on bone and cardiovascular outcomes using UK Biobank data.

This study examines how sex and BMI modify the effect of genetically predicted lower CETP levels on lipid biomarkers and cardiovascular outcomes using observational genetic data.

ExPheWas provides a web-based browser to explore gene-phenotype associations from a pheWAS study in the UK Biobank, identifying potential disease-related genes like MYOT for atrial fibrillation.

The paper identifies a sex-specific evolutionary interaction between ADCY9 and CETP variants associated with dalcetrapib response and cardiovascular traits.