Benoît J. Arsenault

This study shows that lipoprotein(a) promotes thrombosis by enhancing platelet activation and creating lysis-resistant thrombus structures, with effects mitigated by aspirin.

This study identifies VKORC1L1 as a hepatic antioxidant that prevents oxidative stress and protects against MASLD and hepatocellular carcinoma by reducing vitamin K.

This paper introduces a machine learning Mendelian randomization estimator, Quantile IV, to assess the causal effects of sclerostin inhibition on bone and cardiovascular outcomes using UK Biobank data.

This paper evaluates polygenic risk scores (PRS) for CAD and blood lipids to predict CAD incidence in UK Biobank participants.

This paper uses Mendelian randomization to identify 49 blood proteins causally associated with calcific aortic valve disease, revealing immune and growth factor pathways involved in the disease.

This study identifies 71 brain proteins linked to body weight regulation through genetic analysis and shows their association with dietary intake.

This study uses trans-omic Mendelian randomization to identify genes, proteins, and metabolites associated with parental lifespan and potential drug targets for healthspan extension.

This study identifies three new susceptibility genes for calcific aortic valve stenosis through GWAS and TWAS, highlighting roles in inflammation, mineralization, and blood vessel integrity.

This study investigates the association between elevated Lp(a) levels, parental lifespan, and long-term mortality risk using genetic and observational data.

This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.