Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblasts
Silvia Domínguez-García, Javier Rodríguez, Miguel Juliá, Diane Coursier, Carmen Perez-Lopez, Patricia Carnicero, Ana Victoria Villar, Alex von Kriegsheim, Fernando Calvo
This study shows HSP90α maintains YAP activity in cancer-associated fibroblasts, promoting aggressive cancer behaviors through ECM remodeling and tumor growth.
bioRxiv · Apr 4, 2025 · PreprintCancer Biology