Alex von Kriegsheim

Human brown adipose tissue demonstrates substantial 18F-fluorocholine uptake at room temperature for phosphatidylcholine synthesis

This study shows that 18F-fluorocholine PET can detect human brown adipose tissue at room temperature by measuring phosphatidylcholine synthesis, without requiring cold exposure.

mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer

This study identifies mTORC2 as a convergent dependency in lung cancer that stabilizes HIF-1β to drive metabolic adaptation and tumor progression, revealing a therapeutic target in sphingolipid metabolism.

ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology

The paper identifies ER-liquid condensates that sequester FAM134B/C and RhoA, affecting cell morphology and cancer invasion.

Intestinal bacteria hijack an evolutionarily conserved epithelial repair signal

The paper identifies hypoxanthine as a key metabolite released during apoptosis that is consumed by gut bacteria, impairing epithelial repair.

The most common epilepsy-causing mutation in EEF1A2 (E122K) perturbs the translation of specific transcripts but not the rate of global protein synthesis

The paper investigates the E122K mutation in EEF1A2, showing it affects specific transcript translation but not global protein synthesis rate in neurons.

The Single Cell Proteomic blueprint, navigating instrumentation platforms, software tools and high-load libraries in neutrophils, RKO and A549 cells

This study evaluates DIA search engines, high-load libraries, and instrumentation platforms for single-cell proteomics across different cell types.

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This study identifies Molidustat's anti-tumor effect in APC-mutant colorectal cancer through co-inhibition of GSTP1 and PHD2, revealing a synthetic lethal interaction.

A Context-Aware Single-Cell Proteomics Analysis pipeline.

The paper introduces a pipeline for single-cell proteomics analysis that addresses challenges in data processing and annotation using context-aware methods and large language models.

Ubiquitin recognition integrates plant immune signaling by cell-surface and intracellular receptors

This study identifies ubiquitin recognition as the mechanism enabling mutual potentiation between cell-surface and intracellular receptors in plant immunity.

Enhancing Lipid Detection and Spatial Accuracy in Carotid Plaques Using Mass Spectrometry Imaging Techniques

This study improves MALDI-MSI sample preparation for carotid plaque lipid analysis by comparing methods, finding Cryofilm with sublimation best balances tissue preservation and lipid detection.

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

This study shows FAK regulates glycolysis and glutamine oxidation in glioblastoma stem cells, affecting mitochondrial morphology and cell migration.

USP18 Inhibition Enhances Type I Interferon Signalling and Immune Activation in the Tumour Microenvironment of Triple-Negative Breast Cancer

This study shows that inhibiting USP18 enhances type I interferon signaling and immune activation in TNBC, converting immunologically cold tumors into hot ones and improving immunotherapy efficacy.

Dysproteostasis primes pancreatic epithelial state changes in KRAS-mediated oncogenesis

This study shows that proteostatic failure in ER-phagy, driven by Kras, leads to protein aggregates that prime acinar-ductal metaplasia and pancreatic cancer.

Tumour genotype shapes blood biomarker expression for use in pancreatic cancer detection and diagnosis.

This study shows that genetic mutations in PDAC affect blood biomarker profiles, suggesting genotype-specific biomarkers are needed for early detection.

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain

This study shows that H2AK119ub, catalyzed by PRC1, prevents ectopic gene activation by transcription factors during neural differentiation, ensuring proper cell fate restriction in the developing forebrain.

Overcoming preservation challenges to enable single-cell proteomics of fixed cell and tissue samples with retained proteome integrity

This paper develops a method to perform single-cell proteomics on preserved tissues, expanding its applicability by overcoming sample preservation challenges.

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer

This study identifies GPX4 as a therapeutic target in LIMD1-deficient lung cancer by showing its role in ferroptosis susceptibility.

Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblasts

This study shows HSP90α maintains YAP activity in cancer-associated fibroblasts, promoting aggressive cancer behaviors through ECM remodeling and tumor growth.

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.

Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme

The paper shows WT1 and DDX5 regulate the let7/Igf1r axis in kidney mesenchyme, linking WT1 mutations to Wilms Tumour through microRNA and IGF signalling pathways.

Paralog protein compensation preserves protein-protein interaction networks following gene loss in cancer

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.

Dual site proteomic analyses reveal potential drug targets for cardiovascular disease

This paper uses Mendelian randomisation to identify potential drug targets for cardiovascular disease by analysing protein levels in plasma and PBMCs from large cohorts.

TUBB4B variants specifically impact ciliary function, causing a ciliopathic spectrum

The paper identifies TUBB4B mutations causing distinct ciliopathic diseases by affecting microtubule dynamics and cilia formation in humans and mice.

Noise Stress induces Cardiovascular Metabolic Shifts

This study shows that aircraft noise exposure in mice causes rapid metabolic changes in the heart, resembling those in cardiovascular disease.

Identification of a P62-TIF-IA axis that drives nucleolar fusion and the senescence associated secretory phenotype

This study identifies a p62-TIF-IA axis that drives nucleolar fusion and the senescence-associated secretory phenotype (SASP) through ATM-mediated disruption of autophagic degradation.

Planar cell polarity is essential for the architectural patterning of the mammalian biliary tree.

This study shows that planar cell polarity, mediated by VANGL2, is essential for the proper formation and architecture of the mammalian biliary tree.

Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

This study shows that SRSF1 shuttling between nucleus and cytoplasm is essential for ciliogenesis and development, as demonstrated by phenotypic defects in a mouse model with nuclear-retained SRSF1.

Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

The paper shows how periodic GTPase waves coordinate leading and trailing edge dynamics during cell migration through RhoA-Rac1 interactions.

ITPase Deficiency Causes Martsolf Syndrome With a Lethal Infantile Dilated Cardiomyopathy

This paper identifies ITPA mutations causing a lethal infantile dilated cardiomyopathy with Martsolf syndrome features and describes the molecular consequences of ITPase deficiency.