SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain
Huijie Huang, Christina Huan Shi, Wenqi Yang, Juan Piña-Crespo, Jay Bhatnagar, Julian Curatolo, Rabi Murad, Palak Mayur Shah, Alex Rosa Campos, Alexandra K Houser, Rebecca A. Porritt, Tongmei Zhang, Qiang Xiao, Shengjie Feng, Kevin Yuk-Lap Yip, Timothy Y. Huang
This study shows that increasing SORLA levels in aged tauopathy mice reduces multiple pathological effects, including tau phosphorylation, inflammation, and synaptic dysfunction.
bioRxiv · Jun 25, 2025 · PreprintNeuroscience