CBX3 Deletion Overcomes Ferroptosis Resistance in Colorectal Cancer by Targeting IFNγ/SLC7A11/SLC3A2 Axis
Yao Xiang, Yuanji Fu, Christophe Desterke, Éric Batsché, Abdelali Jalil, Rima Elhage, Clémence Duruel, Jean-Christophe Beche, Eric Frapy, David Skurnik, Caroline Reisacher, Sedlik Christine, Eliane Piaggio, Laurence Arbibe, Ahmed Hamaï, Yunhua Chang
This study shows that CBX3 deletion increases ROS and lipid ROS levels in CRC cells, sensitizing them to ferroptosis by disrupting the IFNγ/SLC7A11/SLC3A2 axis.
bioRxiv · Oct 27, 2026 · PreprintCancer Biology