Éric Batsché

CBX3 Deletion Overcomes Ferroptosis Resistance in Colorectal Cancer by Targeting IFNγ/SLC7A11/SLC3A2 Axis

This study shows that CBX3 deletion increases ROS and lipid ROS levels in CRC cells, sensitizing them to ferroptosis by disrupting the IFNγ/SLC7A11/SLC3A2 axis.

Identification of CaVβ1 isoforms required for neuromuscular junction formation and maintenance

This study identifies CaVβ1 isoforms involved in neuromuscular junction formation and maintenance through developmental regulation and functional analysis.

Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis

The paper identifies reduced CBX5 expression and impaired Integrator activity in MS patients, linking them to transcriptomic alterations and disease progression.

The "Alu-ome" shapes the epigenetic environment of regulatory elements controlling cellular defense

The paper identifies Alu elements as dynamic boundaries in regulatory elements, influencing histone modifications and DNA methylation patterns across tissues and age.

Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes

This paper investigates how influenza A virus RNA polymerase (FluPol) interacts with host chromatin during infection, showing it targets regulatory elements of immune response genes and interferes with transcription processes.

Reduced RNA turnover as a driver of cellular senescence

The paper shows that RNA accumulation, driven by reduced RNA turnover and oxidative stress, contributes to the inflammatory state of senescent cells.

CD44 alternative splicing is a sensor of intragenic DNA methylation in tumors

The paper investigates how DNA methylation affects alternative splicing in tumors, finding that meDNA influences splicing patterns and is linked to cancer progression.

Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription

The paper shows that dieldrin activates endogenous retroviruses in MS by triggering multiple signaling pathways and altering transcriptional regulation.