Microengineered transplantation of human solid tumors for in vitro studies of CAR T immunotherapy
Haijiao Liu, Estela Noguera-Ortega, Xuanqi Dong, Won Dong Lee, Jeehan Chang, Sezin Aday, Yumei Li, Yonghee Shin, Xinyi Shi, Maria Liousia, Marina C. Martinez, Joshua J. Brotman, Soyeon Kim, Zeyu Chen, Anni Wang, , Dongeun Huh
This paper develops a microengineered platform to study CAR T cell therapy in human solid tumors, showing improved trafficking and effector function, and identifying therapeutic targets and biomarkers.
Nature Biotechnology · Oct 17, 2025Peer-reviewedBioengineering