Won Dong Lee

This paper develops a bioengineered model of the human placenta to study metal exposure during pregnancy and identifies protective roles of efflux transporters and potential metabolic biomarkers.

This study shows that impaired glycolysis in bone tissue of aged mice leads to reduced bone formation, and that enhancing glycolysis can improve bone mass.

This study develops a microphysiological model of the human oral cavity to study host-microbe interactions during bacterial, fungal, and viral infections.

This study introduces CM-SLP, a platform to identify non-oncology drugs that enhance cancer cell death under altered nutrient conditions by targeting metabolic vulnerabilities.

This study develops a multi-nutrient differential equation model to show how competitive catabolism between glucose, fatty acids, and ketones under fasting conditions leads to systemic metabolic homeostasis, with implications for obesity-induced diabetes.

This paper develops a microengineered platform to study CAR T cell therapy in human solid tumors, showing improved trafficking and effector function, and identifying therapeutic targets and biomarkers.

This study maps spatial metabolic gradients in murine liver and intestine using integrated experimental-computational methods, revealing distinct metabolic patterns and fructose-induced metabolic derangements.

This paper introduces DeepMet, a chemical language model that predicts and discovers unknown metabolites using mass spectrometry data.