Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis
Jeffrey C. Hsiao, Douglas M. Warui, Jason J. Kwon, Margaret B. Dreishpoon, Nolan R. Bick, Tamra Blue-Lahom, David E. Root, Squire J. Booker, Peter Tsvetkov
This study identifies two critical residues in FDX1 essential for both cuproptosis and lipoylation through deep mutational scanning.
Nature Communications · Dec 21, 2025Peer-reviewedCell Biology