Author

Jason J. Kwon

Broad InstituteORCID 0000-0002-3053-2919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

David E. RootiD· 3 shared Rameen BeroukhimiD· 2 shared Sean A. MisekiD· 2 shared William C. HahniD· 2 shared Aaron FultineeriD· 1 shared Adnan HalimiD· 1 shared Alexander Zhang· 1 shared Alexandra Larisa ConduratiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

David E. RootORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedDec 21, 2025

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis

Jeffrey C. Hsiao, Douglas M. Warui, Jason J. Kwon…·Peter Tsvetkov

This study identifies two critical residues in FDX1 essential for both cuproptosis and lipoylation through deep mutational scanning.

32 citationstop 1%

humanexperimental assay

Cancer BiologybioRxivPreprintAug 18, 2025

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

Sean A. Misek, Anna Borgenvik, Daniel Christen…·Pratiti Bandopadhayay

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

1 citation

humanproteomics

Cancer BiologybioRxivPreprintOct 22, 2024

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon, Julien Dilly, Shengwu Liu…·Andrew J. Aguirre

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

13 citations

humanproteomics