A germline KDM3C polymorphism impairs DNA repair and sensitizes to chemoradiotherapy
Adria Hasan, Elena V. Demidova, Pragya Priyadarshini, Philip Czyzewicz, Leonny Gathuka, Takahiko Murayama, Yan Zhou, Z. Kiss, R. Shastry, Mark Andrake, Gavin Hearne, Karthik Devarajan, Chao Wu, Anshul Shah, Bryant M. Schultz, , Sanjeevani Arora
The paper identifies a germline KDM3C polymorphism linked to impaired DNA repair and increased sensitivity to chemoradiotherapy in cancers like rectal and head and neck squamous cell carcinomas.
medRxiv · Aug 31, 2026 · PreprintGenetic & Genomic Medicine