Barbara Ann Burtness

The paper identifies a germline KDM3C polymorphism linked to impaired DNA repair and increased sensitivity to chemoradiotherapy in cancers like rectal and head and neck squamous cell carcinomas.

The paper develops an in vivo mouse model to assess the differential toxicity of cancer drugs on Fanconi Anemia mutant hematopoietic cells and identifies drugs with neutral toxicity.

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.