Yan Zhou

The paper uses single-nucleus RNA-seq and spatial transcriptomics to show how the maternal-fetal interface diverges in structure and function between the basal plate and chorionic membranes, identifying NID2 as an ancestry-associated regulator of trophoblast invasion.

This study identifies TNIK as a regulator of MYC-driven partial EMT in LUSC, supporting proliferation and senescence evasion.

The paper identifies a germline KDM3C polymorphism linked to impaired DNA repair and increased sensitivity to chemoradiotherapy in cancers like rectal and head and neck squamous cell carcinomas.

The paper identifies novel regulators of quiescence-to-proliferation transitions in Drosophila follicle stem cells by analyzing gene expression changes during feeding.

The paper integrates epigenomic features to identify chromatin-state classes and shows Polycomb-associated chromatin drives cell-type-specific differences.

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

The paper uses single-cell RNA sequencing to identify a novel cytotrophoblast population in the smooth chorion of the human placenta that functions as a barrier and restricts EVT invasion.

This study identifies JWA as an aging-associated gene whose deficiency disrupts intestinal epithelial homeostasis and accelerates aging in mice through the Notch1/PPARγ/Stat5 axis.

The paper identifies circPTPN12 as a regulator of miR-21-5p and ΔNp63α in endometrial fibrosis, suggesting it as a therapeutic target.

This study identifies conjugated linolenic acids as ferroptosis inducers in triple-negative breast cancer and shows their anti-tumor effects in a xenograft model.